Erb-B2 receptor tyrosine kinase 2 mRNA 3' untranslated region poly-U sequence (ERBB2 3' UTR poly-U)

The Erb-B2 receptor tyrosine kinase 2 (ERBB2) mRNA 3' untranslated region (UTR) poly-U sequence is a critical post-transcriptional regulatory element located at the 3' end of the HER2 transcript. This uridine-rich sequence serves as a primary docking site for RNA-binding proteins (RBPs), most notably HuR (ELAVL1), which binds to the poly-U tract to enhance mRNA stability and facilitate efficient translation (Source: PubMed, PMID: 23503460). In many malignancies, including HER2-positive breast and gastric cancers, the stabilization of ERBB2 mRNA via this sequence leads to the pathological overexpression of the HER2 protein, driving uncontrolled cell proliferation and survival (Source: UniProt, P04626). Therapeutic interventions targeting this specific RNA sequence, such as antisense oligonucleotides (ASOs) or small molecules that disrupt RBP-mRNA interactions, aim to decrease HER2 protein levels by promoting mRNA decay (Source: Journal of Biological Chemistry). This target represents a novel approach to overcoming resistance to traditional HER2-targeted therapies like trastuzumab by addressing the source of protein production at the genetic message level.

Other names

HER2 mRNA 3' UTR U-rich elementERBB2 3' UTR regulatory elementERBB2 mRNA 3' UTR poly-uridine sequenceHER2 3' UTR URE

Disruption of mRNA-protein interactions (e.g., HuR binding) to promote mRNA degradation or inhibit translation of the ERBB2 transcript.