Estrogen sulfotransferase (SULT1E1) (SULT1E1)

Estrogen sulfotransferase (SULT1E1) is a cytosolic enzyme that plays a pivotal role in the metabolic inactivation of estrogens, specifically estrone and 17β-estradiol [UniProt: P49848]. It catalyzes the transfer of a sulfate group from the donor molecule 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the phenolic hydroxyl group of estrogens, resulting in the formation of inactive estrogen sulfates [PubMed: 22403200]. This enzymatic activity is a key regulator of the local concentration of active estrogens in tissues such as the breast, endometrium, and liver, thereby modulating estrogen receptor-mediated signaling [NCBI Gene: 6783]. In clinical contexts, SULT1E1 is often downregulated in estrogen-dependent cancers, which contributes to increased local estrogen levels and promotes tumor growth [PubMed: 15135305]. Pharmacologically, SULT1E1 is a target for inhibition by various environmental chemicals and dietary flavonoids, which can lead to endocrine disruption or altered steroid homeostasis [PubChem: SULT1E1]. Overall, SULT1E1 serves as a critical metabolic gatekeeper that controls the biological potency of estrogenic hormones throughout the body [PubMed: 20630840].

Other names

Sulfotransferase 1E1STEEstrone sulfotransferaseST1E1Estrone sulfation

SULT1E1 inactivates estrogens by transferring a sulfate group from PAPS to the 3-hydroxy group of estrone or estradiol, preventing their binding to estrogen receptors and facilitating their excretion.