Ether-à-go-go potassium channel (mouse) (mEAG)

The mouse Ether-à-go-go (mEAG) ion channel is a voltage-gated potassium channel belonging to the EAG (Ether-à-go-go) family, orthologous to the human KCNH1 (Kv10.1) channel[3][4][7]. EAG channels are membrane proteins that form potassium-selective pores, opening in response to changes in membrane voltage and contributing to the regulation of cell excitability, particularly in neuronal and some cancer cell contexts[3][7]. The EAG family is named for the original Drosophila mutant that exhibited leg shaking under ether anesthesia. Channels of this family play critical roles in electrical signaling, and their dysregulation has been implicated in tumorigenesis, epilepsy, and cardiac arrhythmia.

Other names

EAG potassium channelKCNH1 (in some contexts, depending on species)Ether-a-go-go-related gene channel (EAG)Kv10.1 (for human ortholog; mouse abbreviation is less commonly used in canonical form)

Potassium channel blockade (by small molecules impedes K+ current)