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ETS proto-oncogene 2, transcription factor (ETS2)
- Target
- ETS2
- Molecular classification
- Transcription factor, Proto-oncogene, DNA-binding protein
01
Overview
ETS proto-oncogene 2, transcription factor (ETS2), is a member of the ETS family of transcription factors that activates transcription by binding specifically to target DNA motifs (GGAA/T, known as Ets-binding sites) in promoters[1][4][6]. It regulates genes involved in cellular proliferation, differentiation, and apoptosis, functions as a proto-oncogene in various diseases, and has also been linked to the regulation of telomerase. ETS2 is implicated in several diseases, including cancers and immune-mediated inflammatory diseases. Its biological activity is mediated through direct DNA binding, transcriptional activation, and involvement in cellular response pathways[1][2][6].
- Other names
- Protein C-ets-2V-Ets avian erythroblastosis virus E26 oncogene homolog 2V-Ets avian erythroblastosis virus E2 oncogene homolog 2V-Ets erythroblastosis virus E26 oncogene homolog 2Oncogene ETS-2ETS2IT1[1][2]
02
Mechanism of action
No identified pharmacological inhibitors or activators; action would typically be through modulation of transcriptional activity if targeted
03
Biological functions
Regulation of gene expressionCell developmentApoptosisRegulation of telomeraseTranscriptional activation
04
Disease associations
CancerChoriocarcinomaEndometrium carcinoma in situInflammatory bowel diseaseTakayasu's arteritisPrimary sclerosing cholangitisAnkylosing spondylitis
05
Safety considerations
Not directly established, but potential risks may include impacts on cell growth and survival, given its role in cell development and apoptosis[1][6]
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