Exocrine pancreatic enzyme (examples: Pancreatic lipase, Pancreatic amylase, Pancreatic proteases) (None (EPI/PEI refer to the condition, not the enzyme))

Pancreatic enzyme deficiency (more accurately called exocrine pancreatic insufficiency, EPI) is a condition in which insufficient pancreatic digestive enzymes are delivered to the small intestine, impairing digestion and nutrient absorption. The primary enzymes affected are pancreatic lipase, amylase, and proteases. EPI commonly results from chronic pancreatitis, cystic fibrosis, pancreatic cancer, or surgical removal of pancreatic tissue, but also arises from genetic syndromes or autoimmune/idiopathic injury to the exocrine pancreas. Clinically, EPI presents with malnutrition, diarrhea, steatorrhea, and vitamin deficiencies, particularly fat-soluble vitamins, and can lead to complications including osteoporosis, growth problems, and immune suppression. Diagnosis is via direct or indirect assessment of pancreatic enzyme output, and treatment relies upon oral supplementation of the missing enzymes (pancreatic enzyme replacement therapy). This term should not be used as a specific drug target; however, individual pancreatic enzymes can be specified for research or therapy.

Other names

Exocrine pancreatic insufficiencyPancreatic exocrine insufficiency

Enzyme supplementation/replacement to restore digestion of dietary fats, proteins, and carbohydrates