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Exonuclease 3'-5' domain containing 3 (EXD3)
- Target
- EXD3
- Molecular classification
- Enzyme, Exoribonuclease
01
Overview
Exonuclease 3'-5' domain containing 3 (EXD3) is a protein-coding human gene that encodes an enzyme with predicted and experimentally supported 3'-5' exoribonuclease activity. EXD3 is required for 3'-end processing of certain microRNAs (AGO1-bound miRNAs), contributes to nucleic acid (DNA and RNA) metabolism, and has metal ion binding capability[1][3][4]. Its up-regulation is associated with increased risk and poorer prognosis in gastric cancer, suggesting a possible role in DNA damage repair and nucleotide metabolism, and making it a proposed candidate for prognostic cancer biomarker development[1][6]. There are currently no approved drugs targeting EXD3 directly, and its precise roles in other disease processes (e.g., thyroid hormone resistance) are not yet clearly characterized.
- Other names
- MUT-7mut-7Nbrnibbler homologHBE269LOC54932FLJ20433testicular tissue protein Li 125exonuclease mut-7 homologexonuclease 3'-5' domain-containing protein 3
02
Biological functions
Nucleic acid binding3'-5' exonuclease activityRNA processing (3'-end trimming of AGO1-bound miRNAs)Metal ion bindingNucleotide metabolismPotential role in DNA damage repair processes[1][2][3]
03
Disease associations
Cancer (notably potential oncogenic role in gastric cancer[1][6])Thyroid hormone resistance (reported association, but not a well-confirmed disease mechanism[3])
04
Biomarkers
Prognostic biomarker in gastric cancer (high EXD3 expression correlates with poor prognosis[1][6])
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