Extracellular matrix protein (and cell surface protein classes) (ECM protein (no universal standard abbreviation for both ECM and cell surface protein classes, but "ECM" is common for extracellular matrix); Cell surface protein (no universal abbreviation))

**Extracellular matrix (ECM) proteins** and **cell surface proteins** represent two overlapping, highly diverse classes of molecules crucial for the structure and function of multicellular organisms. The ECM is a complex, mostly non-cellular network composed of collagen, elastin, fibronectin, laminins, proteoglycans, and glycoproteins, providing physical scaffolding for cells, modulating biochemical signals, influencing migration, proliferation, differentiation, and tissue repair, and contributing to homeostasis and tissue-specific architecture[1][2][3][4][5][6][8]. **Cell surface proteins** (such as integrins, syndecans, and discoidin domain receptors) mediate interactions between cells and the ECM, linking external physical cues to intracellular signaling pathways[2][5]. Both ECM proteins and cell surface proteins are not single drug targets, but encompass a wide array of molecular targets for therapeutic intervention in cancer, fibrosis, inflammatory diseases, and genetic disorders; however, the category as a whole is too broad to be considered a specific therapeutic target for drug development. **Note:** - This entry ("Extracellular Matrix / Cell Surface proteins") is too broad and does not correspond to a specific molecular entity as would be required for a canonical therapeutic target. It covers hundreds of distinct proteins (ECM and cell-surface types) with varying functions, disease associations, and druggability. - For structured information, you should map to individual proteins (e.g., "Integrin alpha V beta 3", "Collagen type I", "Syndecan-1") rather than the entire classes "extracellular matrix protein" or "cell surface protein"[1][2][5][6]. If you need data on a specific ECM or cell surface protein, specify its name or family (such as "integrin alpha 5", "collagen type IV", or "fibronectin").

Other names

Extracellular matrix componentsECM proteinscell membrane proteinscell adhesion proteinsmatrix proteinssurface proteins