Extracellular Matrix Proteins and Cell-Surface Adhesion Molecules (ECM & CAMs) (ECM & CAMs)

Extracellular Matrix (ECM) Proteins and Cell-Surface Adhesion Molecules (CAMs) represent a broad functional class of molecules essential for tissue architecture and intercellular communication. The ECM consists of a complex network of macromolecules, such as collagens, proteoglycans, and glycoproteins, which provide structural support and biochemical signals to surrounding cells (Ref: PMID: 22219366). CAMs, including integrins, cadherins, and selectins, are transmembrane proteins that facilitate physical connections between cells or between a cell and the ECM, playing pivotal roles in cell signaling and migration (Ref: PMID: 11252105). In pathological states, alterations in ECM composition or CAM expression contribute to tumor metastasis, chronic inflammatory infiltration, and the development of fibrosis (Ref: PMID: 24507509). Therapeutic interventions targeting these molecules, such as monoclonal antibodies against specific integrins, are widely used to treat autoimmune disorders and prevent thrombotic events by modulating cell recruitment and adhesion (Ref: PMID: 28853167). Additionally, enzymatic targeting of the ECM is employed in conditions like Dupuytren's contracture to restore tissue flexibility (Ref: PMID: 20163212).

Other names

ECM proteinsCell adhesion moleculesCAMsMatrisome componentsAdhesion receptorsExtracellular matrix components

Inhibition of integrin-mediated cell adhesion, blockade of leukocyte extravasation, competitive inhibition of ligand binding to cell-surface receptors, and enzymatic degradation of structural matrix proteins.