Facilitated glucose transporter (GLUT family) (GLUT (for individual family members, e.g., GLUT1, GLUT4))

Facilitated glucose transport is mediated by a family of intrinsic membrane proteins called facilitative glucose transporters or GLUTs, which efficiently catalyze the bidirectional movement of glucose across the plasma membrane according to its concentration gradient without energy expenditure[1][2][3][5]. Multiple isoforms (GLUT1 to GLUT14 in humans) show tissue specificity, substrate selectivity, and regulation by hormones such as insulin (notably GLUT4 in adipose and muscle)[1][2][5]. These proteins are characterized by 12 transmembrane segments and belong to the major facilitator superfamily of transporters[1][5].\n\nIn summary, \"Facilitated glucose transport\" describes a physiological process, and the proper canonical target entry should be one of the GLUT proteins (e.g., **Facilitated glucose transporter type 1 (GLUT1)** or **Facilitated glucose transporter type 4 (GLUT4)**, etc.), depending on biological context[1][2][5]. The current name is not sufficiently specific and should be corrected for structured data extraction.

Other names

Glucose transporterGLUT familySolute carrier family 2 (SLC2A)Monosaccharide transporter

Insulin promotes translocation of GLUT4 to plasma membrane, increasing glucose uptake in muscle/adipose tissue[1][2][3]\nInhibition or modulation of GLUT expression or function can alter glucose homeostasis