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Target intelligence / Profile preview
Family with sequence similarity 168 member B (FAM168B) (FAM168B)
- Target
- FAM168B
- Molecular classification
- Membrane-associated protein, Intracellular signaling protein, Other
01
Overview
- Other names
- Myelin-associated neurite-outgrowth inhibitor (MANI)KIAA0280Lp20FAM168A (homolog)Tongue cancer resistance-associated protein 1 (TCRP1, homolog)
02
Mechanism of action
Targeting of membrane-associated FAM168B proteins by engineered chimeric antigen receptor (CAR) T-cells to induce tumor cell lysis.
03
Biological functions
Neurite outgrowth inhibitionCell proliferation regulationSignal transductionApoptosis modulation
04
Disease associations
CancerTongue squamous cell carcinomaGlioblastomaBreast cancer
05
Safety considerations
Blood-brain barrier (BBB) penetration riskPotential neurotoxicity due to expression in the central nervous systemOff-target effects on normal myelin-associated tissues
06
Interacting drugs
Experimental CAR T-cells
1 more in the full profile.
07
Biomarkers
FAM168B expression levelsTranscriptional component 168 (TC168) activity scores
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