Family with sequence similarity 217, member B (FAM217B)

Family with sequence similarity 217, member B (FAM217B) is a human protein of unknown function, located primarily in the cytosol and nucleoplasm[1][5]. Studies show that its promoter may undergo hypermethylation and transcriptional silencing in disorders such as ulcerative colitis, where such silencing could contribute to disease pathogenesis, possibly through the disruption of gene expression in intestinal epithelium[1]. While its consistent epigenetic alteration marks it as a gene of interest and a potential biomarker, the biological role of FAM217B—in cellular signaling, immune modulation, or epithelial maintenance—remains to be fully established. There is currently no evidence that FAM217B directly functions as a receptor, enzyme, or other canonical drug target, nor are there known drugs designed to act on this gene product[1][3][5]. FAM217B is primarily notable as an epigenetically regulated gene, with potential biomarker implications; not a characterized receptor, enzyme, or regulated drug target at this time[1][5]. Its most common aliases are C20orf177 and dJ551D2.5, and its function is "uncharacterized protein" or "other" in terms of molecular classification[3][5]. It is recorded as a protein-coding gene with some disease associations by bioinformatic correlation, not by mechanism-driven validation[5].

Other names

C20orf177dJ551D2.59030418K01RikRGD1311952