Family with sequence similarity 84 member B (FAM84B) (FAM84B)

Family with sequence similarity 84 member B (FAM84B), also known as BCMP101 or NSE2, is a membrane-associated protein located on chromosome 8q24.21, a region frequently amplified in various malignancies [NCBI Gene, PMID: 28656234]. It plays a significant role in promoting cell proliferation, migration, and invasion, often by facilitating the epithelial-mesenchymal transition (EMT) and modulating the actin cytoskeleton [UniProt, PMID: 28103569]. FAM84B has been identified as a potential oncogene in several cancers, including prostate, breast, and esophageal squamous cell carcinoma, where its overexpression correlates with poor prognosis and advanced disease stages [PMID: 28656234, PMID: 26918261]. While it is not yet a target for any FDA-approved therapies, its critical role in tumor progression makes it an attractive candidate for future drug development, particularly through the use of targeted inhibitors or gene-silencing technologies [PMID: 30210534]. Research suggests that FAM84B may interact with key signaling pathways like Wnt/beta-catenin to drive oncogenesis [PMID: 28103569]. Additionally, its localization to the plasma membrane and involvement in cell-cell adhesion suggest it may be accessible for antibody-based or small molecule interventions [UniProt].

Other names

NSE2BCMP101Breast cancer membrane-associated protein 101LRAT-like protein 2Protein FAM84B

No approved drugs currently target FAM84B; experimental strategies involve the use of RNA interference (siRNA/shRNA) or potential small molecule inhibitors to suppress its oncogenic activity and downstream signaling pathways such as Wnt/beta-catenin [PMID: 30210534, PMID: 28103569].