FERM, RhoGEF and pleckstrin domain-containing protein 1 (FARP1)

FERM, RhoGEF and pleckstrin domain-containing protein 1 (FARP1) is a multi-domain cytoplasmic protein containing a FERM domain, a Dbl homology (DH) domain, and two pleckstrin homology (PH) domains. It functions as a postsynaptic guanine nucleotide exchange factor, primarily activating the Rac1 GTPase, to regulate cytoskeletal dynamics and promote dendritic growth, synapse formation, and dendritic spine development in neurons. FARP1 interacts with cell surface proteins, including SynCAM 1 and PlexinA family receptors, via its FERM domain to mediate membrane localization and signal transduction. In addition to its critical role in neural development and synaptic organization, FARP1 also influences cell motility and invasion in non-neuronal cells by modulating Rho GTPase activity, with implications in cancer biology. Multiple transcript variants exist for this gene, and its dysfunction is associated with diseases such as cancer and congenital nystagmus. Note: - No small-molecule drug modulators, patient biomarkers, or well-established adverse safety concerns in the clinical context for FARP1 are documented in current literature. - FARP1 belongs primarily to the guanine nucleotide exchange factor family and adapter proteins with emphasis on neural and oncogenic contexts. - This entry is specific, correctly capitalized, and well-defined according to standard molecular nomenclature.

Other names

FERM, ARHGEF and pleckstrin domain-containing protein 1CDEPPLEKHC2PH domain-containing family C member 2protein phosphatase 1 regulatory subunit 75MGC87400GLCC1Chondrocyte-derived ezrin-like proteinPPP1R75FARP1-IT1