Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2 (FGFR1; FGFR2)
- Target
- FGFR1; FGFR2
- Molecular classification
- Receptor tyrosine kinase, Single-pass transmembrane receptor
01
Overview
Fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor receptor 2 (FGFR2) are cell-surface tyrosine-protein kinases that act as high-affinity receptors for fibroblast growth factors (FGFs). Structurally, each consists of three extracellular immunoglobulin-like domains (D1-D3), a single transmembrane helix, and an intracellular split tyrosine kinase domain. Ligand binding triggers receptor dimerization and activation of kinase activity, leading to pathways that control cell proliferation, differentiation, migration, and survival. FGFR1/2 play central roles in embryonic development, tissue homeostasis, angiogenesis, and wound repair. Genetic alterations of FGFR1/2 can drive cancers, skeletal disorders, and other diseases, making them prominent drug targets in oncology and regenerative medicine.
- Other names
- FGFR1 (also known as CD331)FGFR2
02
Mechanism of action
Inhibition of kinase activity (blocking phosphorylation and downstream signal transduction); Disruption of ligand binding; Receptor dimerization blockade
03
Biological functions
Signal transductionCell proliferationCell differentiationMigrationEmbryonic developmentCell survivalAngiogenesisWound healing
04
Disease associations
Cancer (e.g., breast, colon, pancreatic cancer)Developmental disorders (skeletal dysplasia, craniosynostosis)InflammationCardiovascular disease
05
Safety considerations
Hyperphosphatemia (from inhibition of FGF23 signaling)Ocular toxicitySkin toxicitiesGastrointestinal disturbancesRisk of impaired wound healing and developmental toxicity (due to physiological roles of FGFRs)
06
Interacting drugs
Erdafitinib
2 more in the full profile.
07
Biomarkers
FGFR gene mutations or amplifications (e.g., FGFR1/FGFR2 fusions)Protein overexpression (immunohistochemistry on tumor biopsies)
Beyond the preview
Go deeper on Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2 (FGFR1; FGFR2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2 (FGFR1; FGFR2).