Fibroblast growth factor receptor 1 messenger RNA (FGFR1 mRNA) (FGFR1 mRNA)

Fibroblast growth factor receptor 1 (FGFR1) messenger RNA (mRNA) is the transcript produced from the FGFR1 gene, serving as the essential template for the synthesis of the FGFR1 protein, a critical receptor tyrosine kinase (NCBI Gene: 2260). This mRNA plays a vital role in cellular signaling pathways that govern proliferation, survival, and embryonic development (UniProt: P11362). In various cancers, such as non-small cell lung cancer and breast cancer, FGFR1 mRNA is frequently overexpressed due to gene amplification, acting as a potent oncogenic driver (PubMed: 23539236). While most current clinical therapies utilize small-molecule inhibitors to target the FGFR1 protein, the mRNA itself is an attractive target for gene-silencing approaches. Therapeutic strategies such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are designed to bind specifically to the FGFR1 mRNA, leading to its degradation or the inhibition of translation (PubMed: 21602828). By preventing the production of the FGFR1 protein at the source, these RNA-targeted therapies aim to provide a more precise intervention and potentially overcome resistance mechanisms associated with traditional kinase inhibitors.

Other names

FGFR1 transcriptCD331 mRNABFGFR mRNAFLT2 mRNAHBGFR mRNAFibroblast growth factor receptor 1 transcript

Targeted degradation of the mRNA transcript via RNase H-mediated cleavage (for antisense oligonucleotides) or the RNA-induced silencing complex (for siRNAs), which prevents the translation of the FGFR1 protein.