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Target intelligence / Profile preview
Fibroblast growth factor receptor 2 (isoform b) (FGFR2b)
- Target
- FGFR2b
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
Fibroblast growth factor receptor 2b (FGFR2b) is a specific splice isoform of the FGFR2 gene, encoding a transmembrane receptor tyrosine kinase. FGFR2b plays critical roles in embryonic development, tissue repair, and is implicated in various cancers due to its involvement in cell proliferation, differentiation, and angiogenesis. It acts as a high-affinity receptor for FGF7 and FGF10, triggering downstream signaling cascades upon ligand binding. Overexpression or amplification of FGFR2b is observed in cancers, making it a therapeutic target.
- Other names
- CD332FGFR-2bFGFR2 IIIb
02
Mechanism of action
Inhibition of FGFR2b tyrosine kinase activity
03
Biological functions
Cell divisionGrowthDifferentiationEmbryonic developmentTissue repairAngiogenesisSignal transduction
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Potential for off-target effectsResistance development
06
Interacting drugs
Monoclonal antibodies directed at FGFRs
1 more in the full profile.
07
Biomarkers
FGFR2 amplificationFGFR2 overexpression
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