Filamin-B (FLNB) (FLNB)

Filamin-B (FLNB) is a high-molecular-weight cytoskeletal protein responsible for cross-linking actin filaments into three-dimensional networks and anchoring transmembrane proteins to the actin cytoskeleton (UniProt O75369). It plays a fundamental role in vertebrate skeletal development, vascular patterning, and cell migration by acting as a molecular scaffold for various signaling pathways, including those involving focal adhesion kinase (FAK). Mutations in the FLNB gene are associated with a wide spectrum of skeletal dysplasias, such as Larsen syndrome and atelosteogenesis, which present with joint dislocations and bone fusion (PMID: 17164264). In oncology, FLNB is identified as a promoter of cancer cell invasion and metastasis through the regulation of cellular motility (PMID: 25482025). Furthermore, FLNB acts as a host regulator of filovirus entry, influencing the macropinocytosis process required for viruses like Ebola and Marburg to infect cells (PLOS Pathogens, 2023). Therapeutic research focuses on small molecules and flavonoids like artemetin that can bind and modulate Filamin-B function to address invasive cancers and viral infections (Frontiers, 2021).

Other names

Filamin BFLN-BActin-binding protein 278ABP-278Filamin-3FLN3Beta-filaminFH1LRS1SCTTABPTAP

Filamin-B functions as a scaffold and actin-crosslinking protein that organizes the cytoskeleton and facilitates the assembly of signaling complexes (e.g., involving FAK and MRLC) to regulate cell motility. Therapeutic agents like artemetin bind directly to Filamin-B to stabilize its folded state (as demonstrated by DARTS), potentially inhibiting its pathological activity in cancer cell invasion and macropinocytosis-mediated viral entry (Frontiers, 2021; J-Stage, 2014).