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Target intelligence / Profile preview
Fimbriae Types 2 & 3 (Fim2/3)
- Target
- Fim2/3
- Molecular classification
- Protein, Adhesin, Fimbrial subunit
01
Overview
Fimbriae are filamentous protein structures on bacterial surfaces that mediate adhesion, colonization, and biofilm formation. Types 2 and 3 fimbriae are specific variants found in different bacterial species like Bordetella pertussis and uropathogenic Escherichia coli, contributing to virulence by enabling attachment to host tissues. Type 3 fimbriae, particularly, are associated with catheter-associated urinary tract infections.
- Other names
- Type 2 FimbriaeType 3 FimbriaeFim 2Fim 3MrkD adhesin
02
Mechanism of action
Inhibition of bacterial adhesion
03
Biological functions
AdhesionColonizationBiofilm formationAgglutinationImmune evasion
04
Disease associations
InfectionUrinary tract infectionsCatheter-associated urinary tract infectionsPertussis
05
Safety considerations
Potential for off-target effectsDevelopment of resistance
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