Folate-metabolizing enzyme or Folate transporter (see is_incorrect below)

Folate-metabolizing enzymes and transporters are a broad group of molecular targets participating in the cellular processes that use or move folate, an essential B-vitamin required for DNA replication, repair, methylation, and amino acid metabolism. Key enzymes include serine hydroxymethyltransferase (SHMT1 and SHMT2), methylene-THF dehydrogenase (MTHFD1, MTHFD2), and methionine synthase, while the main transporters/receptors are the reduced folate carrier (RFC/SLC19A1), proton-coupled folate transporter (PCFT/SLC46A1), and folate receptor alpha (FRα, FOLR1)[1][2][3][5]. These proteins collectively regulate the uptake of folate from the diet, its cellular distribution, and its biochemical transformations critical for cell growth, nucleotide synthesis, and methylation reactions[2][3]. Dysfunction or altered expression of these molecules can contribute to diseases such as cancer, hereditary folate malabsorption, and cardiovascular or neurodevelopmental disorders[2][3][4][5]. Note: - The query "Folate-metabolizing enzymes and transporters" refers to an entire molecular pathway involving many distinct proteins (multiple enzymes, transporters, and receptors)[1][2][3][5]. A canonical name should be assigned to individual enzymes (e.g., "Serine hydroxymethyltransferase 1") or transporters (e.g., "Reduced folate carrier"), not to a pathway grouping. - Thus, is_incorrect is set to true, since the entry is overly broad and lacks specificity required for a "target molecule/receptor". To be actionable in a structured form, select and specify a single protein (e.g., "Folate receptor alpha", "SLC19A1", "Serine hydroxymethyltransferase 1", "Dihydrofolate reductase").

Other names

Folate pathway enzymesFolate receptorsReduced folate carrier (RFC)Proton-coupled folate transporter (PCFT)Folate receptor alpha (FRα)SLC19A1SLC46A1FOLR1–3

Inhibition of dihydrofolate reductase (DHFR); Inhibition of thymidylate synthase (TS); Blockade of reduced folate carrier (RFC) or PCFT transport