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Fructose-1,6-bisphosphatase
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Fructose-1,6-bisphosphatase (FBPase) is a critical regulatory enzyme in gluconeogenesis, catalyzing the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. This reaction is irreversible and a key control point in glucose production. It is regulated by AMP and fructose 2,6-bisphosphate (inhibition) and ATP (activation). Two main isoforms exist: FBP1 (liver/kidney) and FBP2 (muscle). Deficiency causes hypoglycemia, while overactivity contributes to hyperglycemia in type II diabetes, making it a potential drug target. Increased expression may also play a role in appetite regulation.
02
Mechanism of action
Inhibition of fructose-1,6-bisphosphate hydrolysis
03
Biological functions
GluconeogenesisRegulation of glucose metabolismCalvin cycle (in plants)Muscle thermogenesis
04
Disease associations
Hypoglycemia (deficiency)Hyperglycemia (overactivity)Type II DiabetesAppetite regulation
05
Safety considerations
Potential for hypoglycemia with excessive inhibition
06
Interacting drugs
Lithium
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