Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase B (ALDOA; ALDOB)

Fructose-bisphosphate aldolase A and Fructose-bisphosphate aldolase B are cytosolic enzymes central to glycolysis; each catalyzes the splitting of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase A is predominant in muscle and erythrocytes, while Aldolase B is expressed in the liver, kidney, and small intestine. Aldolase B additionally catalyzes the cleavage of fructose 1-phosphate, crucial for fructose metabolism. Deficiency in Aldolase B leads to hereditary fructose intolerance, a serious metabolic disorder. Structural similarities exist between isozymes, but tissue distribution and minor sequence differences account for their distinct functions and clinical significance. Both are increasingly investigated as metabolic targets in cancer and rare inherited disorders.

Other names

Muscle-type aldolaseFructose-bisphosphate aldolase AALDOALiver-type aldolaseFructose-bisphosphate aldolase BALDOB

Enzyme inhibition: Small molecule inhibitors could block glycolytic function and suppress tumor growth. Gene therapy: For hereditary fructose intolerance, approaches may involve correcting ALDOB gene defects.