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Fungi (via acetic acid-induced cell death)
- Molecular classification
- Other
01
Overview
Fungi are susceptible to acetic acid, which at high concentrations induces regulated cell death through a mechanism involving intracellular acidification, vacuolar permeabilization, protease release (e.g., Pep4p), and increased ROS/caspase-like activity. This pathway presents a potential target for antifungal drug development.
- Other names
- Fungal cell death (acetic acid)Acetic acid-induced fungal apoptosisFungal acetic acid responseFungi and acetic acid
02
Mechanism of action
Induction of regulated cell death via intracellular acidification, vacuolar permeabilization, protease release, and ROS/caspase-like activity.
03
Biological functions
Cell deathMetabolismStress responseGrowth regulation
04
Disease associations
InfectionFood spoilage
05
Safety considerations
Potential for off-target effects on eukaryotic cells.Development of resistance to acetic acid-based treatments.
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