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Target intelligence / Profile preview
FYN proto-oncogene, Src family tyrosine kinase (Fyn)
- Target
- Fyn
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Src family kinase
01
Overview
Fyn is a non-receptor tyrosine kinase belonging to the Src family. It is involved in various cellular processes, including cytoskeletal remodeling, signal transduction, neuronal development, and immune cell function. Dysregulation of Fyn has been implicated in cancer and neurodegenerative diseases.
- Other names
- p59-FynSLKSYNFGRSrc Kinase p59
02
Mechanism of action
Fyn is a tyrosine kinase that phosphorylates target proteins, modulating their activity or creating docking sites for other signaling molecules. It plays a role in various signaling pathways related to cell growth, motility, and differentiation.
03
Biological functions
Cytoskeletal regulationSignal transductionT-cell receptor signalingNeuronal developmentSynaptic transmissionCognitive functionsMemory formationCalcium signalingCell proliferationCell differentiationCell survivalCell motility
04
Disease associations
CancerNeurodegenerative diseaseImmune disorders
05
Safety considerations
Dysregulation can contribute to cancer progression.Aberrant function has been linked with neurodegenerative diseases.Modulates killer cell effector functions.
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