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Target intelligence / Profile preview
Gastric cancer associated transcript 2 (non-protein coding) (GACAT2)
- Target
- GACAT2
- Molecular classification
- Long non-coding RNA (lncRNA), Other (Non-protein-coding RNA)
01
Overview
Gastric cancer associated transcript 2 (GACAT2) is a long non-coding RNA (lncRNA) implicated in various cellular processes, particularly as a regulator in cancer biology. GACAT2 is downregulated in most gastric cancer tissues and is associated with disease progression, distal metastasis, venous invasion, and nerve invasion. Research indicates that GACAT2 can also bind with proteins such as pyruvate kinase M1/2 to regulate mitochondrial function and impact cell differentiation, especially in inflammatory environments. GACAT2 is under investigation primarily as a biomarker for early detection and disease monitoring in gastric cancer, but it is not currently considered a direct therapeutic target, receptor, or enzyme. There are no known drugs that target GACAT2 directly, nor are there established safety concerns regarding its pharmacological manipulation at this time.
- Other names
- HMlincRNA717MTCL1-AS1MTCL1AS1MTCL1 antisense RNA 1GACAT2
02
Biological functions
Regulation of cell proliferationRegulation of cell differentiationModulation of mitochondrial functionInvolvement in inflammation response
03
Disease associations
CancerCancer biomarker (specifically in gastric cancer)Inflammation
04
Biomarkers
Potential biomarker for gastric cancer progression and early disease
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