Gastrin mRNA (GAST mRNA) (GAST mRNA)

Gastrin mRNA is the messenger RNA transcript of the GAST gene, which encodes the preprogastrin precursor protein (UniProt: P01350). This precursor is processed into various bioactive forms of gastrin, primarily gastrin-17 and gastrin-34, which are essential for stimulating gastric acid secretion from parietal cells and promoting the growth of the gastric and colonic mucosa (NCBI Gene ID: 2520). In pathological states, such as gastrinomas or certain gastrointestinal cancers, GAST mRNA is often overexpressed, leading to hypergastrinemia and accelerated tumor cell proliferation (PMID: 15188258). Therapeutic strategies targeting GAST mRNA, such as antisense oligonucleotides or small interfering RNAs, aim to silence the expression of gastrin at the pre-translational level (PMID: 10446449). This approach is intended to control acid hypersecretion in Zollinger-Ellison syndrome and inhibit the trophic effects of gastrin on hormone-dependent malignancies (PMID: 11506514). While no mRNA-targeted therapies for gastrin are currently FDA-approved, research continues into their potential for precision oncology and managing refractory hypersecretory disorders.

Other names

Gastrin messenger RNAGAST transcriptPreprogastrin mRNA

Antisense inhibition or RNA interference (RNAi) leading to mRNA degradation or translational repression, thereby reducing the synthesis of preprogastrin (PMID: 10446449).