Germin-like protein (Citrus sinensis) (Cit s 1)

Germin-like protein Cit s 1 is a glycoprotein allergen isolated from sweet orange (Citrus sinensis). It belongs to the germin-like subfamily within the cupin superfamily of plant proteins. Cit s 1 is identified as a 24 kDa glycoprotein that binds specific IgE in more than 60% of orange-allergic individuals, although only a small subset have positive clinical responses (such as skin reactions) when exposed to purified Cit s 1. Its IgE-binding is heavily dependent on complex N-glycan structures, which can result in false positive diagnosis of orange allergy if based solely on in vitro IgE testing. Cit s 1 does not currently serve as a therapeutic target; its primary significance is as a component allergen in food allergy diagnosis and research.

Other names

Orange germin-like glycoproteinCit s 1 allergenCitrus sinensis allergen 1