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Target intelligence / Profile preview
Glucocorticoid Receptor NR3C1 Subunit Alpha Isoform 1 Variant A (Human) (GR)
- Target
- GR
- Molecular classification
- Nuclear Receptor, Transcription Factor
01
Overview
The glucocorticoid receptor (GR), encoded by the NR3C1 gene, is a ligand-activated transcription factor mediating the effects of glucocorticoids. Upon ligand binding, GR translocates to the nucleus, binds to GREs, and regulates gene expression involved in various physiological processes, including inflammation, metabolism, and immune response. It is a key target for anti-inflammatory drugs, but its widespread expression leads to diverse side effects.
- Other names
- Glucocorticoid ReceptorNR3C1hGRalpha
02
Mechanism of action
Ligand-dependent transcription factor; binds to GREs to activate or repress gene expression
03
Biological functions
Transcriptional regulationStress responseImmune responseInflammationMetabolismCell proliferationCell differentiationApoptosisCircadian rhythm regulation
04
Disease associations
InflammationAutoimmune diseasesCancerMetabolic disordersEndocrine disordersImmunodeficiency
05
Safety considerations
ImmunosuppressionHyperglycemiaOsteoporosisAdrenal suppressionWeight gainIncreased risk of infectionCushing's syndrome
06
Interacting drugs
Cortisol
6 more in the full profile.
07
Biomarkers
NR3C1 expression levelsCortisol levelsACTH levelsInflammatory markers (e.g., CRP, IL-6)
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