Target intelligence / Profile preview

Glucosaminyl (N-Acetyl) Transferase 3 (GCNT3)

Target: GCNT3
Molecular classification: Enzyme, Glycosyltransferase

Overview

GCNT3 is a glycosyltransferase enzyme that catalyzes the formation of core 2 and core 4 O-glycan branches on mucin-type glycoproteins. It also exhibits I-branching activity. Altered expression or function of GCNT3 has been linked to Colorectal Cancer (CRC) and Epithelial Ovarian Cancer (EOC), making it a potential prognostic and predictive biomarker. It is involved in cellular cycle regulation, mitosis/proliferation pathways, drug response mechanisms, and metabolism.

Other names: Core 2/I branching beta-1,6-N-acetylglucosaminyltransferaseC2GnT-M

Mechanism of action

N/A

Biological functions

Core 2 and core 4 O-glycan branchingBiosynthesis of mucinsI-branching enzyme activityO-linked glycosylation

Disease associations

CancerColorectal Cancer (CRC)Epithelial Ovarian Cancer (EOC)Bejel disease

Biomarkers

CRC prognosisCRC therapy responseEOC treatment outcomesSensitivity to chemotherapy (e.g., 5-fluorouracil)

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