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Target intelligence / Profile preview
Glucose Transporter (Cellular) (GLUT)
- Target
- GLUT
- Molecular classification
- Transporter, Membrane protein, Solute Carrier Family
01
Overview
Glucose transporters are membrane proteins that facilitate the movement of glucose across cellular membranes. They are essential for cellular energy supply. The main families are GLUTs (facilitative transporters) and SGLTs (sodium-glucose linked transporters). Different isoforms like GLUT1, GLUT2, GLUT3, and GLUT4 are expressed in various tissues and play distinct roles in glucose homeostasis. Defects or deficiencies in specific transporter isoforms can lead to disease.
- Other names
- Glucose TransportersGLUTsSGLTsSodium-Glucose Linked TransportersSLC2A1SLC2A2SLC2A3SLC2A4
02
Mechanism of action
Facilitated diffusion of glucose across cellular membranes down a concentration gradient; Secondary active co-transport of glucose and sodium across cellular membranes using sodium gradient
03
Biological functions
Glucose transportFacilitated diffusionSecondary active transportGlucose homeostasisCellular energy supplyBlood-brain barrier maintenanceGlucose sensing
04
Disease associations
DiabetesGLUT1 deficiency syndromeFanconi-Bickel syndromeCongenital renal glycosuriaMalabsorption syndromesNeurological disorders
05
Safety considerations
Hypoglycemia (with insulin and some SGLT inhibitors)Drug-drug interactionsSpecific toxicities related to transporter inhibition in certain tissues (e.g., renal effects with SGLT inhibitors)
06
Interacting drugs
Insulin
1 more in the full profile.
07
Biomarkers
Blood glucose levelsHbA1cGLUT expression levels in tissue biopsies
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