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Target intelligence / Profile preview
Glutamate [GluN2B] Subunit-containing N-methyl-D-aspartate Receptor (NR2B)
- Target
- NR2B
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Glutamate receptor, NMDA receptor
01
Overview
The GluN2B subunit-containing N-methyl-D-aspartate receptor (NMDA receptor) is a subtype of ionotropic glutamate receptors in the central nervous system. It is a heterotetrameric complex composed of two GluN1 subunits and two GluN2B subunits, encoded by the GRIN2B gene. These receptors function as ligand-gated ion channels, mediating Ca2+, Na+ influx and K+ efflux upon glutamate binding. The GluN2B subunit confers high affinity for CaMKII, which is crucial for long-term potentiation (LTP). Dysregulation has been implicated in neurodegenerative diseases due to its role in excitotoxicity, and alterations in GRIN2B are linked to various neurological disorders.
- Other names
- NR2BNMDAR2BNMDA receptor subunit 2BNMDA receptor NR2BN-methyl D-aspartate receptor subtype 2BHNR3epsilon-2
02
Mechanism of action
Selective antagonism of GluN2B subunit-containing NMDA receptors
03
Biological functions
Synaptic transmissionSynaptic plasticityLong-term potentiation (LTP)Calcium signalingNeuronal excitabilityLearningMemory
04
Disease associations
Neurodegenerative diseaseNeurodevelopmental disordersIntellectual disabilityEpilepsyAutism spectrum disorderSchizophrenia
05
Safety considerations
ExcitotoxicityNeurodegenerationPotential for cognitive side effects
06
Interacting drugs
Ifenprodil
2 more in the full profile.
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