Glutamate [N-methyl-D-aspartate] receptor subunit epsilon-2 (GluN2B)

The GluN2B subunit-containing NMDA receptor is a subtype of glutamate receptor—a ligand-gated ion channel mediating excitatory neurotransmission in the central nervous system. NMDA receptors are heterotetrameric complexes typically consisting of two GluN1 and two GluN2 subunits (GluN2A-D), with GluN2B conferring distinct channel and pharmacological properties. GluN2B-containing NMDA receptors are highly expressed in the developing brain and certain adult regions, including forebrain and cortex. They play key roles in synaptic plasticity, learning, memory, and pain processing, and their dysregulation is implicated in multiple neuropsychiatric and neurodegenerative conditions. Selective inhibition of GluN2B-containing NMDA receptors is a validated therapeutic strategy for CNS disorders, though side effects remain a challenge.

Other names

NR2B subunitGluN2BGRIN2BGluRε2GluR2BNMDA receptor subunit epsilon-2

Allosteric inhibition (binding to NR2B-specific sites to block NMDA receptor function) - Channel block (preventing Ca²⁺ influx through the receptor) - Modulation of synaptic localization and receptor trafficking - Reduction of glutamatergic neurotransmission - Interference with downstream excitotoxic signaling