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Target intelligence / Profile preview
Glutamate receptor, ionotropic kainate 5 (GluK5)
- Target
- GluK5
- Molecular classification
- Ionotropic glutamate receptor, Kainate receptor, Ligand-gated ion channel, Receptor
01
Overview
The kainate receptor subunit GluK5 (GRIK5) is a component of the ionotropic glutamate receptor family. It is a high-affinity subunit that requires co-assembly with other kainate receptor subunits (GluK1-3) to form a functional ion channel. GluK5 plays a role in modulating synaptic transmission, synaptic plasticity, and neuronal circuit activity. Studies suggest its involvement in the pathophysiology of depression and contextual memory.
- Other names
- KA2GRIK5GLUKA(II)GRI KKA₂GRI K₅
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
Synaptic transmission modulationRegulation of neurotransmitter releasePostsynaptic response modulationSynaptic plasticityRegulation of neuronal circuit activity
04
Disease associations
DepressionSchizophrenia
05
Interacting drugs
L-glutamate
1 more in the full profile.
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