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Target intelligence / Profile preview
Glutamate receptor 3 (AMPA subtype) (GluA3)
- Target
- GluA3
- Molecular classification
- Ionotropic glutamate receptor, AMPA receptor, Receptor, Ion channel
01
Overview
Glutamate receptor 3, also known as GluA3 or GluR3, is a subunit of AMPA-type ionotropic glutamate receptors, which mediate fast excitatory neurotransmission in the central nervous system. It is encoded by the GRIA3 gene. AMPA receptors are tetrameric complexes composed of combinations of GluA1–GluA4 subunits. GRIA3 plays a critical role in synaptic plasticity, learning, and memory. Variants and dysfunction in GRIA3 have been linked to epilepsy, intellectual disability, and schizophrenia risk. It is predominantly expressed postsynaptically in the cortex and hippocampus.
- Other names
- GLUR-CGLUR-K3GLURCGluR3MRX94
02
Mechanism of action
Ligand-gated ion channel activation, leading to Na+ and K+ influx and neuronal depolarization.
03
Biological functions
Fast excitatory neurotransmissionSynaptic plasticityGlutamate bindingCation channel activityDepolarization
04
Disease associations
EpilepsyIntellectual DisabilitySchizophreniaCancer
05
Safety considerations
Neuronal damage related to autoantibodiesPotential for excitotoxicity
06
Interacting drugs
Glutamate
2 more in the full profile.
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