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Glutamate Receptor Ionotropic, NMDA 1 (NMDA Receptor)
- Target
- NMDA Receptor
- Molecular classification
- Ion channel, Receptor, Glutamate receptor, Ligand-gated ion channel
01
Overview
The NMDA receptor (N-methyl-D-aspartate receptor) is a subtype of ionotropic glutamate receptors that plays a central role in excitatory neurotransmission, synaptic plasticity, and neurodevelopment in the mammalian central nervous system. It is an obligate heterotetramer typically composed of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. Activation requires co-agonist binding of glycine and glutamate, and channel opening is voltage-dependent due to Mg²⁺ block. The receptor mediates Ca²⁺ influx critical for various physiological processes, but dysregulation can lead to excitotoxicity and involvement in various neurological disorders.
- Other names
- NMDARGluN1/GluN2 heterotetramer
02
Mechanism of action
Channel blocker; Agonist; Allosteric modulator
03
Biological functions
Synaptic transmissionSynaptic plasticityLearning & memoryNeuronal developmentExcitatory neurotransmission
04
Disease associations
ExcitotoxicityStrokeTraumaAlzheimer's diseaseNeurodegenerative diseaseSchizophreniaPsychiatric conditionsPulmonary arterial hypertension
05
Safety considerations
ExcitotoxicityNeuronal injuryNeuronal deathDysregulation in neurological disorders
06
Interacting drugs
Memantine
5 more in the full profile.
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