Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glutamate receptor ionotropic, NMDA 2A (GluN2A)
- Target
- GluN2A
- Molecular classification
- Receptor, Ion channel, Ionotropic glutamate receptor
01
Overview
Glutamate receptor ionotropic, NMDA 2A (GluN2A) is a subunit of the NMDA receptor, a glutamate-gated ion channel crucial for excitatory neurotransmission, synaptic plasticity, learning, memory, and brain development. NMDA receptors are heterotetrameric complexes, typically with two GluN1 and two GluN2 subunits. GluN2A-containing receptors contribute to long-term potentiation and synaptic plasticity. Mutations in GRIN2A, the gene encoding GluN2A, can cause epilepsy and other neurological disorders due to altered NMDA receptor function and neuronal excitability.
- Other names
- GRIN2ANMDAR epsilon 1NMDAR NR_ε_1NMDAR RII-AEpsilon-receptor
02
Mechanism of action
NMDA receptor modulation
03
Biological functions
Synaptic plasticityLearningMemoryCNS developmentExcitatory neurotransmission
04
Disease associations
EpilepsySeizuresNeurological disorders
05
Safety considerations
Excessive neuronal excitationNeuronal death
Beyond the preview
Go deeper on Glutamate receptor ionotropic, NMDA 2A (GluN2A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glutamate receptor ionotropic, NMDA 2A (GluN2A).