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Glutamate receptor ionotropic, NMDA 2B subunit (GluN2B)
- Target
- GluN2B
- Molecular classification
- Ion channel, Receptor, Ligand-gated ion channel, Glutamate receptor
01
Overview
The glutamate receptor ionotropic, NMDA 2B subunit (GluN2B), encoded by the GRIN2B gene, is a critical component of the NMDA receptor complex. It functions as a ligand-gated cation channel with high calcium permeability. GluN2B-containing NMDA receptors are especially important during early brain development and play essential roles in synaptic plasticity, learning, and memory. Mutations in GRIN2B are associated with neurodevelopmental disorders. GluN2B also acts as a mediator for stroke damage, making it a therapeutic target for drug discovery efforts.
- Other names
- NR2BNMDAR2BNR3NMDA receptor subunit 2BNMDAR NR2BHNR3Glutamate [NMDA] receptor subunit epsilon-2
02
Mechanism of action
Modulation of NMDA receptor activity
03
Biological functions
Synaptic plasticityLong-term potentiationLearning and memory formationNeural patterningLong-term depressionExcitatory neurotransmission
04
Disease associations
Neurodevelopmental disordersIntellectual disabilityDelayed speech/motor skillsSeizuresHypotoniaMovement disordersBehavioral problemsAutism spectrum disorderEpilepsyStrokeExcitotoxicity
05
Safety considerations
Potential for excitotoxicityOff-target effects on other NMDA receptor subtypesComplex subunit-specific pharmacology
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