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Glutamate receptor ionotropic, NMDA subunit 2B (None)
- Target
- None
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
Glutamate receptor ionotropic, NMDA subunit 2B (GluN2B, NR2B) is a subunit of the NMDA receptor, an ionotropic glutamate receptor. It plays a crucial role in synaptic plasticity, learning, memory, and neural development. Alterations in GRIN2B, the gene encoding GluN2B, are associated with intellectual disability, neuropsychiatric conditions, and stroke.
- Other names
- GluN2BNR2BNMDAR subunit epsilon-2NMDA receptor subunit 3 (historical)
02
Mechanism of action
Voltage-dependent channel block (Mg²⁺), Allosteric inhibition (Zn²⁺), Allosteric modulation (Polyamines), Selective antagonism (Ifenprodil)
03
Biological functions
Synaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)Neural developmentSynaptic transmission
04
Disease associations
Intellectual disabilityDevelopmental delayNeuropsychiatric disordersStrokeNeurodevelopmental disorders
05
Safety considerations
Excitotoxicity (overactivation contributing to neuronal death in stroke)
06
Interacting drugs
Mg²⁺
3 more in the full profile.
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