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Target intelligence / Profile preview
Glutamate receptor ionotropic, NMDA type (NMDA receptor)
- Target
- NMDA receptor
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor
01
Overview
The NMDA receptor is a subtype of ionotropic glutamate receptors that functions as a ligand-gated ion channel. It plays a central role in excitatory neurotransmission in the central nervous system (CNS), mediating synaptic plasticity, neuronal development, and memory formation. The receptor is permeable to calcium (Ca²⁺), sodium (Na⁺), and potassium (K⁺) ions. It requires co-binding of both glutamate and glycine for activation and is voltage-dependent due to Mg²⁺ block at resting membrane potentials.
- Other names
- NMDARNMDA-RGlutamate receptor ionotropic NMDA
02
Mechanism of action
Ion channel blocker; receptor agonist/antagonist
03
Biological functions
Synaptic transmissionSynaptic plasticityLearningMemory formationNeuronal developmentExcitatory neurotransmission
04
Disease associations
Ischemic strokeTraumatic brain injuryAlzheimer’s diseaseEpilepsyMood disordersSchizophreniaNeurodegenerative disease
05
Safety considerations
ExcitotoxicityOveractivation can lead to neuronal damage
06
Interacting drugs
Memantine
4 more in the full profile.
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