Glutamate receptor ionotropic, NMDA type subunit (NR (e.g., NR1, NR2A, NR2B, NR2C, NR2D, NR3A, NR3B) or GluN (GluN1, GluN2A, etc.))

The **NMDA receptor ionotropic, NMDA type subunits** are integral membrane proteins (GluN1, GluN2A-D, GluN3A-B) that assemble as heterotetramers to form the NMDA receptor, a ligand-gated ion channel permeable to Ca²⁺, Na⁺, and K⁺ ions. Activation requires glutamate and either glycine or D-serine as co-agonists, and opening the receptor channel leads to calcium influx and cellular signaling pathways governing plasticity, development, and repair. NMDA receptor subunits are highly regulated by alternative splicing, post-translational modifications, and interactions with intracellular proteins, determining their localization and function. Dysfunction or excessive activity contributes to neurological and psychiatric diseases, making them key drug targets[1][2][3][4][5][7].

Other names

NMDA receptor subunitNR1NR2ANR2BNR2CNR2DNR3ANR3BGluN1GluN2AGluN2BGluN2CGluN2DGluN3AGluN3B

Antagonists block the ion channel (noncompetitive or competitive inhibition), reducing calcium influx Partial agonists modulate receptor activity Allosteric modulators alter channel opening or ligand binding