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glutamic-oxaloacetic transaminase 2, mitochondrial pseudogene

Overview

The "glutamic-oxaloacetic transaminase 2, mitochondrial pseudogene" (ENSG00000256450) is a genomic DNA segment related to the gene encoding aspartate aminotransferase, mitochondrial (GOT2), but it does not produce a functional protein. Pseudogenes arise from gene duplication or retrotransposition events and accumulate mutations that prevent their expression or function. Unlike its parent gene GOT2, which is a key mitochondrial enzyme of central carbon metabolism and a validated cancer target, this pseudogene has no established biological or clinical relevance[1][5].

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