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Target intelligence / Profile preview
Glutaminase Kidney Isoform, Mitochondrial (GLS)
- Target
- GLS
- Molecular classification
- Enzyme, Amidohydrolase
01
Overview
The glutaminase kidney isoform, mitochondrial (GLS), is a phosphate-activated amidohydrolase enzyme localized in the mitochondria. It catalyzes the hydrolysis of glutamine to glutamate and ammonia, which is essential for renal acid-base homeostasis and cellular metabolism. It is a therapeutic target in cancer due to the "glutamine addiction" of tumor cells, and inhibitors like CB-839 are being investigated.
- Other names
- KGA (Kidney-type Glutaminase)GAC (Glutaminase C)Glutaminase 1GLS1
02
Mechanism of action
Inhibition of glutamine hydrolysis, depriving cancer cells of essential metabolites.
03
Biological functions
Ammonia productionGlutamine metabolismAcid-base homeostasisGlutamate production
04
Disease associations
Cancer
05
Interacting drugs
CB-839 (telaglenastat)
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