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Target intelligence / Profile preview
Gluten-specific CD4+ T Cell (N/A)
- Target
- N/A
- Molecular classification
- T cell receptor, CD4+ T lymphocyte, Immune cell
01
Overview
Gluten-specific CD4+ T cells are essential mediators of celiac disease pathogenesis due to their unique ability to recognize deamidated dietary antigens presented by specific MHC class II alleles. Their highly restricted antigen specificity, distinctive phenotype upon activation/exposure to gluten, key role in orchestrating both humoral autoimmunity and local inflammation make them critical targets for diagnostic assays as well as emerging therapeutic strategies focused on restoring tolerance or selectively modulating pathogenic immunity in celiac disease patients.
- Other names
- Gluten-reactive CD4+ T cellGliadin-specific CD4+ T cellProlamin-specific CD4+ T cell
02
Mechanism of action
Immunomodulation; Tolerance induction; Selective suppression of pathogenic responses
03
Biological functions
Antigen presentation recognitionCytokine productionT cell activationB cell helpAdaptive immune responseInflammation
04
Disease associations
Celiac diseaseAutoimmunityIntestinal inflammation
05
Safety considerations
Broad immunosuppressionOff-target effectsLoss of immune protection
06
Biomarkers
IFN-γ productionIL-21 productionPD-1 expressionICOS expressionOX40 expressionCD28 expressionKi67 expression
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