Target intelligence / Profile preview

Glyceraldehyde-3-phosphate Dehydrogenase, Glycosomal (None)

Target: None
Molecular classification: Enzyme, Oxidoreductase

Overview

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), glycosomal form, is an enzyme that catalyzes the sixth step of glycolysis: the conversion of glyceraldehyde 3-phosphate (GAP) to 1,3-bisphosphoglycerate. In trypanosomatid parasites, this enzyme is localized within specialized organelles called glycosomes. Glycosomal GAPDH is essential for ATP production in bloodstream-form trypanosomes and is a potential drug target for diseases like African sleeping sickness and Chagas disease due to differences between parasite and host enzymes.

Mechanism of action

Inhibition of glyceraldehyde-3-phosphate dehydrogenase activity

Biological functions

GlycolysisATP production

Disease associations

InfectionAfrican sleeping sicknessChagas disease

Safety considerations

Potential for off-target effects if inhibitors are not selective for the parasite enzyme

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