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Target intelligence / Profile preview
Glycine Site of N-methyl-D-aspartate (NMDA) Receptor (NMDA Receptor Glycine Site)
- Target
- NMDA Receptor Glycine Site
- Molecular classification
- Ligand-binding domain, Receptor Subunit, NMDA Receptor Component
01
Overview
The glycine site is a modulatory binding site located on the GluN1 subunit of the NMDA receptor, a subtype of ionotropic glutamate receptors. It is strychnine-insensitive and distinct from classical inhibitory glycine receptors. This site requires either glycine or D-serine as a co-agonist, along with glutamate, for NMDA receptor activation. The glycine/D-serine binding acts allosterically to facilitate NMDA receptor function, which is critical for synaptic plasticity, learning, memory formation, and neurodevelopment. Its dysfunction is implicated in neurological disorders.
- Other names
- NMDA Receptor Glycine Binding SiteGluN1 Glycine SiteStrychnine-insensitive glycine binding site
02
Mechanism of action
Allosteric modulation of NMDA receptor activity; Co-agonist binding for channel opening
03
Biological functions
Modulation of NMDA receptor activityRegulation of synaptic plasticityFacilitation of excitatory neurotransmission
04
Disease associations
SchizophreniaNeurodegenerative diseasesNeurological disorders involving NMDAR hypofunction
05
Safety considerations
Potential for excitotoxicity if NMDA receptor activity is excessively enhanced
06
Interacting drugs
Glycine
3 more in the full profile.
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