Glycogen phosphorylase (muscle isoform) (none)

Glycogenolysis stimulation in skeletal muscle is not a discrete molecular target or receptor, but rather a metabolic process governed by the enzyme glycogen phosphorylase (muscle isoform), which catalyzes the breakdown of glycogen to glucose-1-phosphate during muscle contraction or adrenergic stimulation. This process is essential for rapid ATP generation and is tightly regulated by allosteric and covalent modification mechanisms involving phosphorylase kinase, adenyl cyclase, cAMP, and catecholamines such as epinephrine and norepinephrine[3][4][2]. The activity of the muscle isoform of glycogen phosphorylase is critical for exercise performance and energy metabolism in skeletal muscle, and its disorder results in specific metabolic diseases.

Other names

Muscle glycogen phosphorylasePYGMGlycogen phosphorylase, muscle form

Catalyzes phosphorolytic cleavage of glycogen to produce glucose-1-phosphate during muscle contraction and adrenergic stimulation[3][4]