Target intelligence / Profile preview

Glycoprotein B (human cytomegalovirus) (gB)

Target: gB
Molecular classification: Viral Fusion Protein, Glycoprotein

Overview

Glycoprotein B (gB) is a highly conserved, essential envelope protein of human cytomegalovirus (HCMV). It functions as the primary fusogen for HCMV, mediating virus attachment and membrane fusion with host cells, as well as cell-to-cell spread. It is a target for vaccine and therapeutic antibody development.

Mechanism of action

Viral entry inhibition via fusion interference

Biological functions

Membrane fusionHost cell entryCell-to-cell spread

Disease associations

InfectionHCMV-related diseaseCongenital cytomegalovirus infection

Safety considerations

Elicits mostly non-neutralizing antibodiesPartial vaccine efficacy when used alone

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