Golgi alpha-1,2-mannosidase IA, IB, and IC (MAN1A1, MAN1A2, MAN1C1)

Golgi alpha-1,2-mannosidases IA, IB, and IC are members of the glycoside hydrolase family 47 (GH47) and localize predominantly to the Golgi apparatus in mammalian cells. They catalyze the hydrolysis of terminal alpha-1,2-linked mannose residues from Man8-9GlcNAc2 intermediates, yielding Man5GlcNAc2, a key step in the maturation of N-linked glycoproteins. This action is crucial for proper glycoprotein folding, trafficking, and quality control, and these enzymes contribute to both normal glycoprotein processing and endoplasmic reticulum-associated degradation (ERAD) by generating glycan signals that mark misfolded proteins for degradation. Dysregulation or inhibition of these enzymes can influence disease processes such as cancer and congenital disorders of glycosylation.

Other names

Golgi alpha-mannosidase IGolgi mannosidase I subfamilyGlycoside hydrolase family 47 (GH47) mannosidasesMAN1A1 (Mannosidase alpha class 1A member 1, "mannosidase IA")MAN1A2 (Mannosidase alpha class 1A member 2, "mannosidase IB")MAN1C1 (Mannosidase alpha class 1C member 1, "mannosidase IC")

Competitive inhibition of the alpha-1,2-mannosidase active site by structural analogs of mannose or transition-state mimics, preventing processing of N-linked glycans and altering glycoprotein maturation