Target intelligence / Profile preview

Grass Pollen Allergens (Lolium perenne, Phleum pratense, Poa pratensis)

Molecular classification
Protein allergens
01

Overview

Grass pollen allergens from *Lolium perenne* (perennial ryegrass), *Phleum pratense* (timothy grass), and *Poa pratensis* (Kentucky bluegrass) are significant causes of IgE-mediated allergic reactions. These temperate grasses have similar allergenic profiles and contribute to seasonal allergic rhinitis and asthma. Major allergens include Group 1 and Group 5 proteins (e.g., Lol p 1, Lol p 5, Phl p 1, Phl p 5). There is extensive cross-reactivity among temperate grasses. Standardized extracts are used for diagnosis and allergen immunotherapy.

Other names
Lolium perenne pollenPhleum pratense pollenPoa pratensis pollenPerennial ryegrass pollenTimothy grass pollenKentucky bluegrass pollenGroup 1 grass allergensGroup 5 grass allergensLol p 1Lol p 5Phl p 1Phl p 2Phl p 5Phl p 6
02

Mechanism of action

Allergen immunotherapy induces tolerance by modulating the immune response to specific allergens. Antihistamines block histamine receptors, reducing allergy symptoms. Corticosteroids reduce inflammation.

03

Biological functions

Antigen presentationIgE bindingMast cell activationAllergic sensitization
04

Disease associations

Allergic rhinitisAllergic conjunctivitisAsthmaThunderstorm asthma
05

Safety considerations

Anaphylaxis (rare with immunotherapy)Side effects of antihistamines (drowsiness, dry mouth)Side effects of corticosteroids (long-term use complications)
06

Interacting drugs

Antihistamines

2 more in the full profile.

07

Biomarkers

Specific IgE levels to grass pollen allergens (Lol p 1, Phl p 1, Phl p 5, etc.)Skin prick test reactivity to grass pollen extracts

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