Growth factor receptor-bound protein 2 mRNA (GRB2 mRNA) (GRB2 mRNA)

Growth factor receptor-bound protein 2 (GRB2) mRNA is the template for the synthesis of the GRB2 adapter protein, which plays a pivotal role in intracellular signal transduction (UniProt P62993). GRB2 contains one SH2 domain and two SH3 domains, allowing it to link activated receptor tyrosine kinases, such as the epidermal growth factor receptor (EGFR), to the Ras/MAPK pathway (PubMed: 25639146). This pathway is frequently overactive in various malignancies, driving uncontrolled cell proliferation and survival. Therapeutic strategies targeting GRB2 mRNA utilize antisense oligonucleotides, such as Prexigebersen (BP1001), to bind specifically to the mRNA sequence, triggering its degradation or blocking translation (Bio-Path Holdings). By reducing the levels of GRB2 protein, these therapies aim to inhibit the downstream signaling cascades that promote tumor growth and resistance to treatment. Clinical development has primarily focused on hematological malignancies like acute myeloid leukemia, where GRB2 is a key mediator of oncogenic signaling from proteins like BCR-ABL or FLT3 (ClinicalTrials.gov: NCT01159028). The use of liposomal delivery systems for these antisense molecules helps in overcoming the challenges of cellular uptake and stability in the bloodstream.

Other names

ASH mRNAGrb2 mRNAMST084 mRNAMSTP084 mRNAEGFRBP-GRB2 mRNA

Antisense oligonucleotide-mediated inhibition of translation, leading to downregulation of GRB2 protein expression.