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Target intelligence / Profile preview
Growth factor release (VEGF, bFGF, GM-CSF) from human keratinocytes and fibroblasts
- Molecular classification
- Secreted protein, Cytokine, Growth factor
01
Overview
The release of growth factors such as Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) from human keratinocytes and fibroblasts plays a central role in tissue repair, angiogenesis, inflammation modulation, and wound healing.
02
Mechanism of action
Modulation of growth factor release affects downstream signaling pathways regulating angiogenesis, cell proliferation, and inflammation.
03
Biological functions
AngiogenesisWound healingCell proliferationExtracellular matrix depositionImmune response modulationInflammation modulation
04
Disease associations
Chronic woundsPathological scarringAbnormal tissue remodelingCancerInflammationDiseases of abnormal blood vessel formation
05
Safety considerations
Excessive angiogenesisUncontrolled cell proliferationDysregulated inflammation
06
Biomarkers
VEGF levelsbFGF levelsGM-CSF levels
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